Antimatter chemistry3/11/2023 Many of antimicrobials are structurally complex organic molecules, which are often chemically synthesized from fossil derived feedstock, the process of which requires energy intensive processing and is considered by many as non-sustainable for the future. The student will be closely supervised and receive appropriate training in medicinal chemistry, molecular modelling, organic/peptide chemistry, analytical techniques, and molecular biology.Ĭhemo-enzymatic Synthesis and Potential Applications of Novel antimicrobial peptidesĬhemo-enzymatic Synthesis and Potential Applications of Novel antimicrobial We will collaborate with pharmaceutical companies after the identification of potent in vitro enzyme inhibitors. The chosen enzyme(s) will be produced within the group of Dr Deng and enzymatic assays will be developed to test synthetic molecules and our collection of natural products. This work will be performed in the group of Dr Trembleau. The successful candidate will carry out molecular modelling studies to design inhibitors based on known conserved coronavirus enzymes and study the preparation of selected compounds. The aim of the proposed research is to design and prepare several peptidomimetic inhibitors of key coronavirus enzymes to help to develop effective antiviral drugs against SARS-CoV-2 (for example, see ref 1 and 2). These inequalities and the possible emergence of even more dangerous variants is a cause for great concern, and many pharmaceutical companies have also been trying to develop effective antiviral drugs. Some of the poorest countries have not had access to mass vaccination programmes yet. Over 7 months after the first roll out of vaccinations against SARS-CoV-2, only the richest countries in the world have been able to vaccinate a significant proportion of their population. Effective vaccines against various variants of SARS-CoV-2 (virus causing COVID-19) have rapidly been developed but the production of large quantities of vaccines to protect the world population is challenging and expensive. They can cause mild human illnesses such as the common cold or more serious respiratory diseases as seen in the recent outbreaks of SARS (2002), MERS (2012), and the COVID-19 pandemic (2019). Such studies have relevance for medical PET scanning (Positron Emission Tomography) and antiproton-beam cancer therapy.ĭevelopment of antiviral peptidomimetic enzyme inhibitors against SARS-CoV-2Ĭoronaviruses are a large group of viruses that circulate and evolve among various animals. We also have research programme in computational chemistry investigating the interactions of antimatter with atoms and molecules. The strategy has been to strengthen the link between discovery, synthesis and biosynthesis in order to create chemical diversity with potent and selective biological and pharmacological activity. Research includes the discovery, analysis, metabolic profiling and synthesis of molecules of biological and medical significance. Pioneering work includes the development of elemental speciation and elemental bioimaging methodologies for solving pertinent problems in environmental and biosciences. Research is focussed on the synthesis and investigation of sustainable materials for photocatalysis, heterogeneous catalysis, energy conversion and storage. The Advanced Materials theme brings expertise in materials synthesis, characterization and modelling to tackle important challenges in liquid crystals, electrical and magnetic materials and biomaterials.
0 Comments
Leave a Reply.AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |